Endocrine Abstracts

Receptor for advanced glycation end-products (RAGE) signalling, crucial for diabetic macroangiopathy, is also highly suspected to be involved in atherogenesis in the setting of preserved glucose metabolism.Aim: To determine the relationships between peripheral blood concentrations of RAGE agonists, namely amfoterin (HMBG1) and carboxy-methylo-lisine (CML) as well as RAGE inhibitor Endogenously Secretory RAGE (esRAGE), and the severity of atherosclerosis ...

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...